A few disconnection strategies for the retrosynthesis of this conjugated ketone. This video shows how you can split up a 1,4-diX...

A retrosynthesis of the diketone known as dimedone. The functionality suits disconnections that use enolate and conjugate addition...

Diastereoselective retrosynthesis of blastmycinone, using selective enolisation methods and a consideration of the Felkin-Anh model....

A quick introductory level retrosynthesis, followed by an explanation of some of the relevant mechanisms for a proposed synthesis....

My commentary on the mechanism of a Swern oxidation, a widely used transformation in organic chemistry. I also outline my favourite...

An introduction to diastereoselective aldol reactions using soft enolisation techniques to selectively synthesise one enolate geometry...